Ultima-TB-500 10mg

TB-500 is a synthetic variant of the naturally occurring peptide found in nearly all human and animal cells, known as Thymosin Beta 4 (TB-500). It stands out as a first-in-class drug candidate that facilitates:

   Differentiation of endothelial (blood vessel) cells
   Angiogenesis (the formation of new blood vessels from existing ones) within dermal tissues
   Migration of keratinocytes
   Deposition of collagen; and
   Reduction of inflammation.

One of the primary mechanisms through which TB-500 operates is by regulating the cell-structural protein, Actin, which is essential for cell architecture and movement. Out of the myriad of proteins in cells, actin constitutes up to 10% of the total proteins, thus playing a crucial role in the cell’s genetic framework.

This powerful peptide belongs to a widespread family of 16 related molecules that exhibit a high degree of sequence conservation and are found in most tissues and circulating cells throughout the body. TB-500 not only interacts with actin but also inhibits actin polymerization, serving as the actin-sequestering molecule in eukaryotic cells.

TB-500 has been identified as a gene that is up-regulated four to six times during the initial stages of blood vessel formation, promoting the development of new blood cells from pre-existing vessels. This peptide is present in wound exudate and, when administered via subcutaneous injection, it aids in wound healing, muscle development, and accelerates the recovery of muscle fibers and their cells.

Another significant aspect of TB-500 is its ability to encourage cell migration through a specific interaction with actin within the cell cytoskeleton. Studies have shown that a central small amino acid long-actin binding domain possesses both characteristics of blood cell proliferation and wound healing. These properties are revealed by enhancing the migration of endothelial cells and keratinocytes while also increasing the secretion of enzymes that degrade the extracellular matrix.

Research indicates that TB-500 serves as a potent, naturally occurring factor for wound repair with anti-inflammatory effects. Unlike other repair factors, such as growth factors, TB-500 promotes the migration of endothelial and keratinocyte cells. Additionally, it does not bind to the extracellular matrix and features a low molecular weight, allowing it to traverse considerable distances through tissues.